n.
1.
Distress, wretchedness, woe, tribulation, desolation, sorrow, grief, affliction, heartache, heavy heart, bleeding heart, broken heart, great unhappiness, suffering, anguish, torment.
2.
Distress, suffering, wretchedness, agony, torture, torment, anguish.
3.
Calamity, misfortune, disaster, evil.