DESPAIR

vt to cause to despair.

2. despair ·noun that which is despaired of.

3. despair ·noun loss of hope; utter hopelessness; complete despondency.

4. despair ·vt to give up as beyond hope or expectation; to despair of.

5. despair ·vi to be hopeless; to have no hope; to give up all hope or expectation;

— often with of.