/loh"koh/ , n. , pl. locos , v. , locoed, locoing , adj.
n.
1. locoweed.
2. Slang. an insane person; maniac.
3. Vet. Pathol. locoism.
v.t.
4. to poison with locoweed.
5. Slang. to cause to be insane or crazy.
adj.
6. Slang. out of one's mind; insane; crazy.
[ 1835-45, Amer.; ]