adv. or adj. phr. 1. In the place where you live or come from. I went to his house, but he was not at home. Americans abroad are protected by the government like Americans at home. 2. Knowing what to do or say; familiar; comfortable. Charles and John enjoy working together because they feel at home with each other. The politician was at home among poor farmers and among rich factory owners. Make the new student feel at home in your school. Would you be at home driving a truck? Jim always lived by a lake, and he is at home in the water. Tom has read many books about missiles and is at home in that subject.
Synonym: AT EASE 2 .
Compare: IN ONE'S ELEMENT, MAKE ONESELF AT HOME.
Antonym: AT A LOSS.