Historic wagon trail from Independence , Missouri, to Santa Fe , New Mexico, U.S. An important commercial route from 1821 to 1880, it was opened by
From the {{link=Missouri River">Missouri River the trail followed the divide between the tributaries of the Arkansas and Kansas rivers to the site of modern Great Bend, Kan., then proceeded along the Arkansas River. At the western end three routes turned south to Santa Fe, the shortest being the Cimarron Cutoff through the valley of the Cimarron River . When the Santa Fe railroad was completed in 1880, use of the trail ceased.