FETAL ALCOHOL SYNDROME

(FAS) various congenital abnormalities in the newborn infant that are caused by the mother's ingestion of significant amounts of alcohol around the time of conception or during pregnancy. The principal symptoms of a child born with fetal alcohol syndrome are retarded growth both before and after birth; various abnormalities of the central nervous system; and certain characteristic abnormalities of the face and head. The latter include microcephaly (small head); short palpebral fissures (small eye openings); ptosis (eyelid droop); epicanthic folds (skin folds over the inside eye corner); short, upturned nose; long, smooth philtrum (area between nose and mouth); thin upper lip; and a small jaw. The central nervous system abnormalities result in mental retardation, delayed intellectual development, and various behavioral problems such as poor concentration, impulsiveness, and an inability to consider the consequences of one's actions. Behavioral problems may be the principal symptoms in persons who show little sign of facial abnormalities or mental retardation. Persons born with FAS may also have abnormalities of the upper respiratory passageways, heart, and joints and limbs. FAS is apparently caused by the effects of ethanol (alcohol) or its breakdown product (acetaldehyde) on the developing human embryo or fetus. FAS occurs with a frequency of anywhere from 0.5 to 3 live births per thousand in Western countries. The syndrome commonly appears in the newborns of mothers who are chronic alcoholics. The more heavily a mother drinks during pregnancy, the greater the risk to the developing fetus. It is estimated that between 30 and 40 percent of all women who drink heavily during pregnancy will have a child afflicted with FAS. Although not strictly defined, the phrase heavy drinking can be quantified as a daily intake of 8 or more drinks, amounting to 4 ounces or more of absolute alcohol. Even moderate consumption of alcohol during pregnancy, however, may be associated with milder symptoms of FAS, and women are often counseled to abstain from imbibing any amount of alcohol shortly before and during pregnancy. Prolonging this period of abstinence throughout the duration of breast-feeding is also advised because various other disorders of the newborn have been linked to alcohol in breast milk.