MITCHELL, PETER DENNIS

born , Sept. 29, 1920, Mitcham, Surrey, Eng. died April 10, 1992, Bodmin, Cornwall British chemist who won the 1978 Nobel Prize for Chemistry for helping to clarify how ADP (adenosine diphosphate) is converted into the energy-carrying compound ATP (adenosine triphosphate) in the mitochondria of living cells. Mitchell received his Ph.D. from the University of Cambridge in 1950. He served as director of the chemistry and biology unit in the department of zoology of the University of Edinburgh from 1955 to 1963. In 1964 he joined the Glynn Research Laboratories as director of research. Mitchell studied the mitochondrion, the organelle that produces energy for the cell. ATP is made within the mitochondrion by adding a phosphate group to ADP in a process known as oxidative phosphorylation. Mitchell was able to determine how the different enzymes involved in the conversion of ADP to ATP are distributed within the membranes that partition the interior of the mitochondrion. He showed how these enzymes' arrangement facilitates their use of hydrogen ions as an energy source in the conversion of ADP to ATP.