1.
If you mess something up or if you ~, you cause something to fail or be spoiled. (INFORMAL)
When politicians mess things up, it is the people who pay the price...
He had messed up one career...
If I messed up, I would probably be fired.
PHRASAL VERB: V n P, V P n (not pron), V P
2.
If you ~ a place or a thing, you make it untidy or dirty. (INFORMAL)
I hope they haven’t messed up your video tapes.
PHRASAL VERB: V P n (not pron), also V n P
3.
If something messes someone up, it causes them to be very confused or worried, or to have psychological problems. (INFORMAL)
That really messed them up, especially the boys.
PHRASAL VERB: V n P, also V P n (not pron)