GUAYULE Meaning of GUAYULE in English n. 1 a silver-leaved shrub, Parthenium argentatum, native to Mexico. 2 a rubber substitute made from the sap of this plant. [ Amer. Sp. f. Nahuatl cuauhuli ] Concise Oxford English dictionary. Краткий оксфордский словарь английского языка. 2012