Synonyms and related words :
Schmerz, ache, aches and pains, afflict, agitate, angst, anguish, anxiety, bitterness, bleakness, boredom, bother, burden, care, cheerlessness, comfortlessness, depression, difficulty, discomposure, discontent, dislike, dismalness, dismay, displeasure, disquiet, dissatisfaction, distress, distressfulness, disturb, dolor, dread, dreariness, dullness, emptiness, ennui, existential woe, flatness, grief, grieve, grievousness, grimness, hardship, hurt, hurting, inconvenience, inquietude, irritation, joylessness, lack of pleasure, lament, lamentability, lamentation, load with care, malaise, misery, mourn, mournfulness, nausea, nongratification, nonsatisfaction, nuisance, pain, painfulness, pathos, perturb, pitiability, pitiableness, pitifulness, poignancy, put to it, regrettableness, sadness, savorlessness, sharpness, soreness, sorrow, sorrowfulness, spleen, staleness, suffering, tastelessness, tediousness, tedium, trouble, twinge, uncomfortableness, unease, uneasiness, unhappiness, unpleasure, unsatisfaction, upset, vexation, vexation of spirit, woebegoneness, woefulness, worry