I. preposition
Etymology: Middle English
: without being blocked or prevented by the opposing force of : regardless of the adverse effect of : despite , notwithstanding
went in spite of the rain
a handsome man in spite of his baldness
plunged ahead in spite of all efforts to stop him
II. preposition
: in defiance or contempt of
charged in spite of superior enemy forces
: despite adverse effects of : in opposition to all efforts of
in spite of careful preparation