v. 25B6; verb
the smallest things may irritate you : ANNOY, vex, make angry, make cross, anger, exasperate, irk, gall, pique, nettle, put out, antagonize, get on someone's nerves, try someone's patience, ruffle someone's feathers, make someone's hackles rise; infuriate, madden, provoke; Brit. rub up the wrong way; informal aggravate, miff, rile, needle, get to, bug, hack off, get under someone's skin, get/put someone's back up, get up someone's nose, give someone the hump, drive mad/crazy, drive round the bend/twist, drive up the wall; Brit. informal wind up, get on someone's wick; N. Amer. informal tee off, tick off, rankle, ride, gravel.
some sand irritated my eyes : INFLAME, aggravate, hurt, chafe, abrade, scratch, scrape, graze.
pacify, soothe.