IRRITATE Meaning of IRRITATE in English v. a. 1.Provoke, nettle, chafe, incense, exasperate, enrage, anger, fret, offend, vex, annoy, tease, gall.2.( Med. ) Inflame ( by friction ), excite, stimulate. Soule. Dictionary of English synonyms. Словарь английских синонимов. 2012