ir ‧ ri ‧ tate /ˈɪrəteɪt, ˈɪrɪteɪt/ BrE AmE verb [transitive]
[ Date: 1500-1600 ; Language: Latin ; Origin: past participle of irritare 'to cause strong feelings in, excite' ]
1 . to make someone feel annoyed or impatient, especially by doing something many times or for a long period of time:
It really irritates me when he doesn’t help around the house.
2 . to make a part of your body painful and sore:
This cream may irritate sensitive skin.