LOUSE UP

{v.}, {slang} To throw into confusion; make a mess of; spoil; ruin. * /When the man who was considering John's house heard that the basement was wet, that was enough to louse up the sale./ * /Fred's failure in business not only lost him his business but loused him up with his wife./ * /The rain loused up the picnic./ See: MESS UP(2), FUCK UP.