Synonyms and related words :
affliction, bitter cup, bitter draft, bitter draught, bitter pill, burden, burden of care, cankerworm of care, care, cross, crown of thorns, curse, distress, encumbrance, gall, gall and wormwood, grievance, infliction, load, oppression, peck of troubles, sea of troubles, sorrow, thorn, trouble, waters of bitterness, weight, woe