n. phr. -From baseball. Two opportunities wasted in some undertaking, so that only one chance is left. Poor John has two strikes against him when it comes to his love for Frances: first, he is too fat, and, second, he is bald.
TWO STRIKES AGAINST ONE
Meaning of TWO STRIKES AGAINST ONE in English
American idioms English vocabulary. Английский словарь американских идиом. 2012