{n. phr.}-From baseball. Two opportunities wasted in some undertaking, so that only one chance is left. * /Poor John has two strikes against him when it comes to his love for Frances: first, he is too fat, and, second, he is bald./
TWO STRIKES AGAINST ONE
Meaning of TWO STRIKES AGAINST ONE in English
Slang English vocab. Английский сленговый словарь. 2012