1.
If you strike out , you begin to do something different, often because you want to become more independent.
She wanted me to strike out on my own, buy a business.
...a desire to make changes and to strike out in new directions.
PHRASAL VERB : V P , V P
2.
If you strike out at someone, you hit, attack, or speak angrily to them.
He seemed always ready to strike out at anyone and for any cause...
Frampton struck out blindly, hitting not Waddington, but an elderly man.
PHRASAL VERB : V P at n , V P
3.
If someone strikes out , they fail. ( AM INFORMAL )
The lawyer admitted that he was the firm’s second lawyer. The first one had struck out completely.
PHRASAL VERB : V P
4.
see also strike 19