1.
If you ~, you begin to do something different, often because you want to become more independent.
She wanted me to ~ on my own, buy a business.
...a desire to make changes and to ~ in new directions.
PHRASAL VERB: V P, V P
2.
If you ~ at someone, you hit, attack, or speak angrily to them.
He seemed always ready to ~ at anyone and for any cause...
Frampton struck out blindly, hitting not Waddington, but an elderly man.
PHRASAL VERB: V P at n, V P
3.
If someone strikes out, they fail. (AM INFORMAL)
The lawyer admitted that he was the firm’s second lawyer. The first one had struck out completely.
PHRASAL VERB: V P
4.
see also strike 19