HILL, A.V.

born Sept. 26, 1886, Bristol, Gloucestershire, Eng. died June 3, 1977, Cambridge A.V. Hill, detail of a pencil drawing by F.W. Schmin, 1923 in full Archibald Vivian Hill British physiologist and biophysicist who received (with Otto Meyerhof) the 1922 Nobel Prize for Physiology or Medicine for discoveries concerning the production of heat in muscles. His research helped establish the origin of muscular force in the breakdown of carbohydrates with formation of lactic acid in the absence of oxygen. At the University of Cambridge (1911-14) Hill began his investigations of the physiological thermodynamics of muscle and nerve tissue. Working with a straplike thigh muscle in the frog, he was able to demonstrate that oxygen is needed only for the recovery, not the contractile, phase of muscular activity, laying the foundation for the discovery of the series of biochemical reactions carried out in muscle cells that results in contraction. A professor of physiology at Manchester University (1920-23) and at University College, London (1923-25), he served as Foulerton research professor of the Royal Society from 1926 until his retirement in 1951. His written works include Muscular Activity (1926), Muscular Movement in Man (1927), and Living Machinery (1927). Hill also derived a mathematical expression-known as the "Hill equation"-for the uptake of oxygen by hemoglobin.