1.
If something comes off, it is successful or effective.
It was a good try but it didn’t quite ~...
PHRASAL VERB: V P
2.
If someone comes off worst in a contest or conflict, they are in the worst position after it. If they ~ best, they are in the best position.
Some Democrats still have bitter memories of how, against all odds, they came off worst during the inquiry...
PHRASAL VERB: V P adv
3.
If you ~ a drug or medicine, you stop taking it.
...people trying to ~ tranquillizers.
PHRASAL VERB: no passive, V P n
4.
You say ‘~ it’ to someone to show them that you think what they are saying is untrue or wrong. (INFORMAL, SPOKEN)
CONVENTION