1.
to be successful in your career :
He never really made it as an actor.
2.
to succeed in reaching a place in time, especially when this is difficult :
The flight leaves in twenty minutes—we'll never make it.
3.
to be able to be present at a place :
I'm sorry I won't be able to make it (= for example, to a party) on Saturday.
4.
to survive after a serious illness or accident; to deal successfully with a difficult experience :
The doctors think he's going to make it.
I don't know how I made it through the week.