born Nov. 27, 1857, London, Eng.
died March 4, 1952, Eastbourne, Sussex
English physiologist.
By studying animals whose cerebral cortexes had been removed, he showed that reflexes are integrated activities of the total organism, not based on isolated "reflex arcs." Sherrington's law states that when one set of muscles is stimulated, muscles opposing their action are inhibited. He showed that the role of proprioception in reflexes that maintain upright posture against gravity is independent of cerebral function and skin sensation. His work influenced the development of brain surgery and treatment of nervous disorders, and he coined the terms neuron and synapse . His classic work is The Integrative Action of the Nervous System (1906). In 1932 he shared a Nobel Prize with Edgar Adrian (18891977).