1. adv. phr. Actively engaged in a task as if doing combat. "You want to know whether he will make a diligent worker?" Dick asked. "Well, I can tell you that most of the time he is up and at them like no one else I know." 2. v. phr. To become aggressively engaged in doing something; (useable as a command). Come on, up and at them, you guys. We still have a lot of work to get done.
UP AND AT THEM
Meaning of UP AND AT THEM in English
American idioms English vocabulary. Английский словарь американских идиом. 2012