1. {adv. phr.} Actively engaged in a task as if doing combat. * /"You want to know whether he will make a diligent worker?" Dick asked. "Well, I can tell you that most of the time he is up and at them like no one else I know."/ 2. {v. phr.} To become aggressively engaged in doing something; (useable as a command). * /Come on, up and at them, you guys. We still have a lot of work to get done./
UP AND AT THEM
Meaning of UP AND AT THEM in English
Slang English vocab. Английский сленговый словарь. 2012